Basar Bilgicer, Mark H Kaplan. Allergen-Specific IgE Inhibitors Block Anaphylactic Responses by Targeting Allergen Recognition. The Journal of Allergy and Clinical Immunology2024; S0091-6749 (24) 00074
2023
Jaeho Shin, Baksun Kim, Tyson W Lager, Franklin Mejia, Ian Guldner, Clay Conner, Siyuan Zhang, Athanasia D Panopoulos, Basar Bilgicer. A nanotherapeutic approach to selectively eliminate metastatic breast cancer cells by targeting cell surface GRP78. Nanoscale2023; 10.1039/D3NR00800B
Nada S Alakhras, Jaeho Shin, Scott A Smith, Anthony L Sinn, Wenwu Zhang, Gyoyeon Hwang, Jenna Sjoerdsma, Emily K Bromley, Karen E Pollok, Basar Bilgicer, and Mark H Kaplan. Peanut allergen inhibition prevents anaphylaxis in a humanized mouse model. Science Translational Medicine 2023; 15(682), eadd6373
Sabrina Khan, Franklin Mejia, Jaeho Shin, Gyoyeon Hwang, David T Omstead, Junmin Wu, Sara L Cole, Laurie E Littlepage, Basar Bilgicer. Disease-driven engineering of peptide-targeted DM1 loaded liposomal nanoparticles for enhanced efficacy in treating multiple myeloma by exploring DM1 prodrug chemistry. Biomaterials 2023; 292, 121913
Jenna Sjoerdsma, Franklin Mejia, Basar Bilgicer. Determination of immunogenic epitopes in major house dust mite allergen, Der p 2, via nanoallergens. Annals of Allergy, Asthma & Immunology2022; 129(2), 231-240.
Yongyao Fu, Abigail Pajulas, Jocelyn Wang, Baohua Zhou, Anthony Cannon, Cherry Cheuk Lam Cheung, Jilu Zhang, Huaxin Zhou, Amanda Jo Fisher, David T Omstead, Sabrina Khan, Lei Han, Jean-Christophe Renauld, Sophie Paczesny, Hongyu Gao, Yunlong Liu, Lei Yang, Robert M Tighe, Paula Licona-Limón, Richard A Flavell, Shogo Takatsuka, Daisuke Kitamura, Jie Sun, Basar Bilgicer, Catherine R Sears, Kai Yang, Mark H Kaplan. Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. Nature Communications 2022; 13(1), 3811.
Nada Salem Alakhras, Jaeho Shin, Scott Smith, Basar Bilgicer, Mark H Kaplan. Covalent heterobivalent inhibitor effectively inhibits anaphylaxis to peanut allergen in a humanized mouse model. The Journal of Immunology2022; 208(1_supplement), 49.02.
Franklin Mejia, Sabrina Khan, Basar Bilgicer. Liposomal Targeting Modifies Endosomal Escape: Design and Mechanistic Implications. ACS Biomaterials Science & Engineering 2022; 8(3), 1067-1073.
Franklin Mejia, Sabrina Khan, David T Omstead, Christina Minetos, Basar Bilgicer. Identification and optimization of tunable endosomal escape parameters for enhanced efficacy in peptide-targeted prodrug-loaded nanoparticles. Nanoscale 2022; 14(4), 1226-1240.
David T Omstead, Franklin Mejia, Jenna Sjoerdsma, Baksun Kim, Jaeho Shin, Sabrina Khan, Junmin Wu, Tanyel Kiziltepe, Laurie E Littlepage, Basar Bilgicer. In vivo evaluation of CD38 and CD138 as targets for nanoparticle-based drug delivery in multiple myeloma. Journal of Hematology & Oncology 2020; 13(1), 1-15.
Baksun Kim, Jaeho Shin, Junmin Wu, David T Omstead, Tanyel Kiziltepe, Laurie E Littlepage, Basar Bilgicer. Engineering peptide-targeted liposomal nanoparticles optimized for improved selectivity for HER2-positive breast cancer cells to achieve enhanced in vivo efficacy. Journal of Controlled Release 2020; 322, 530-541.
Nada Salem Alakhras, Jaeho Shin, Scott S Smith, Basar Bilgicer, Mark H Kaplan. Blocking of mast cell-mediated passive anaphylaxis to peanut using covalent heterobivalent inhibitor in a humanized mouse model. The Journal of Immunology 2020; 204 (1_supplement), 66.9.
Baksun Kim, Jaeho Shin, Basar Bilgicer. How could nanoallergen technology be used as a diagnostic tool for allergies? Nanomedicine 2020; 15(11), 1063-1066.
Baksun Kim, Jaeho Shin, Tanyel Kiziltepe, Basar Bilgicer. Identification of a moderate affinity CD22 binding peptide and in vitro optimization of peptide-targeted nanoparticles for selective uptake by CD22+ B-cell malignancies. Nanoscale 2020; 12(21), 11672-11683.
Jared F Stefanick, David T Omstead, Jonathan D Ashley, Peter E Deak, Nur Mustafaoglu, Tanyel Kiziltepe, Basar Bilgicer. Optimizing design parameters of a peptide targeted liposomal nanoparticle in an in vivo multiple myeloma disease model after initial evaluation in vitro. Journal of Controlled Release 2019; 311, 190-200.
David A Khan, Aleena Banerji, Jonathan A Bernstein, Basar Bilgicer, Kimberly Blumenthal, Mariana Castells, Daniel Ein, David M Lang, Elizabeth Phillips. Cephalosporin allergy: current understanding and future challenges. The Journal of Allergy and Clinical Immunology: In Practice 2019; 7(7), 2105-2114.
Peter E Deak, Baksun Kim, Byunghee Koh, Amina Abdul Qayum, Tanyel Kiziltepe, Mark H Kaplan, Basar Bilgicer. Covalent heterobivalent inhibitor design for inhibition of IgE-dependent penicillin allergy in a murine model. The Journal of Immunology 2019; 203(1), 21-30.
David T Omstead, Jenna Sjoerdsma, Basar Bilgicer. Polyvalent nanoobjects for precision diagnostics. Annual Review of Analytical Chemistry 2019; 12, 69-88.
Peter E Deak, Baksun Kim, Amina Abdul Qayum, Jaeho Shin, Girish Vitalpur, Kirsten M Kloepfer, Matthew J Turner, Neal Smith, Wayne G Shreffler, Tanyel Kiziltepe, Mark H Kaplan, Basar Bilgicer. Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen. Proceedings of the National Academy of Sciences 2019; 116(18), 8966-8974.
Peter E Deak, Baksun Kim, Ather Adnan, Marina Labella, Leticia De las Vecillas, Mariana Castells, Basar Bilgicer. Nanoallergen Platform for the Detection of Platin Drugs Allergies. The Journal of allergy and clinical immunology 2019;
Jared Francis Stefanick, David Thomas Omstead, Tanyel Kiziltepe, Basar Bilgicer. Dual-receptor targeted strategy in nanoparticle design achieves tumor cell selectivity through cooperativity. Nanoscale 2019; 11(10), 4414-4427.
Franklin Mejia, Tanyel Kiziltepe, Basar Bilgicer. Supramolecular Assemblies for Macrophage Activation in Cancer Therapy. Trends in Cancer 2018; 4(11), 713-714.
Peter E Deak, Amina Abdul Qayum, Joseph Riehm, Tanyel Kiziltepe, Mark H Kaplan, Basar Bilgicer. Nanoallergens: A Nanoparticle Based Platform for Assessment of Immunogenic Peanut Epitopes in a Clinical Population. Journal of Allergy and Clinical Immunology 2018; 141(2), AB239
Basar Bilgicer, Tanyel Kiziltepe, David Omstead. Dual carfilzomib and doxorubicin carrying nanoparticles for synergistic efficacy in multiple myeloma. Cancer Research 2017; 77(13_Supplement), 2200.
Peter E Deak, Maura R Vrabel, Tanyel Kiziltepe, Basar Bilgicer. Determination of crucial immunogenic epitopes in major peanut allergy protein, Ara h2, via novel nanoallergen platform. Scientific reports 2017; 7(1), 1-13.
Nur Mustafaoglu, Tanyel Kiziltepe, Basar Bilgicer. Site-specific conjugation of an antibody on a gold nanoparticle surface for one-step diagnosis of prostate specific antigen with dynamic light scattering. Nanoscale 2017; 9(25), 8684-8694.
Jonathan D Ashley, Charissa J Quinlan, Valerie A Schroeder, Mark A Suckow, Vincenzo J Pizzuti, Tanyel Kiziltepe, Basar Bilgicer. Dual carfilzomib and doxorubicin–loaded liposomal nanoparticles for synergistic efficacy in multiple myeloma. Molecular cancer therapeutics 2016; 15(7), 1452-1459.
Peter E Deak, Maura R Vrabel, Vincenzo J Pizzuti, Tanyel Kiziltepe, Basar Bilgicer. Nanoallergens: A multivalent platform for studying and evaluating potency of allergen epitopes in cellular degranulation. Experimental Biology and Medicine 2016; 241(9), 996-1006.
Nur Mustafaoglu, Tanyel Kiziltepe, Basar Bilgicer. Antibody purification via affinity membrane chromatography method utilizing nucleotide binding site targeting with a small molecule. Analyst 2016; 141(24), 6571-6582.
Nur Mustafaoglu, Nathan J Alves, Basar Bilgicer. Oriented immobilization of Fab fragments by site-specific biotinylation at the conserved nucleotide binding site for enhanced antigen detection. Langmuir 2015; 31(35), 9728-9736.
Jared F Stefanick, Tanyel Kiziltepe, Basar Bilgicer. Improved peptide-targeted liposome design through optimized peptide hydrophilicity, ethylene glycol linker length, and peptide density. Journal of Biomedical Nanotechnology 2015; 11(8), 1418-1430.
Nur Mustafaoglu, Nathan J Alves, Basar Bilgicer. Site‐specific fab fragment biotinylation at the conserved nucleotide binding site for enhanced ebola detection. Biotechnology and Bioengineering 2015; 112(7), 1327-1334.
Jonathan D. Ashley, Jared F. Stefanick, Valerie A. Schroeder, Mark A. Suckow, Nathan J. Alves, Rikio Suzuki, Shohei Kikuchi, Teru Hideshima, Kenneth C. Anderson, Tanyel Kiziltepe and Basar Bilgicer. Liposomal Carfilzomib Nanoparticles Effectively Target Multiple Myeloma Cells and Demonstrate Enhanced Efficacy In Vivo. Journal of Controlled Release2014; in print.
Jared F. Stefanick, Tanyel Kiziltepe and Basar Bilgicer. Improved Peptide-Targeted Liposome Design through Optimized Peptide Hydrophilicity, Ethylene Glycol Linker Length, and Peptide Density. Journal of Biomedical Nanotechnology2014; in print.
Michael W. Handlogten, Peter E. Deak and Basar Bilgicer. Two-Allergen Model Reveals Complex Relationship Between IgE Crosslinking and Degranulation. Chemistry and Biology2014; in print.
Nathan J. Alves, Nur Mustafaoglu and Basar Bilgicer. Conjugation of a Reactive Thiol at the Nucleotide Binding Site (NBS) for Site-Specific Antibody Functionalization. Bioconjugate Chemistry2014; 25(7) 1198-1202.
Michael W. Handlogten, Jared S. Stefanick, Peter E. Deak and Basar Bilgicer. Affinity-Based Precipitation via a Bivalent Peptidic Hapten for the Purification of Monoclonal Antibodies. Analyst2014; 139(17) 4247-4255.
Jonathan D. Ashley, Jared F. Stefanick, Valeri A. Schroeder, Mark A. Suckow, Tanyel Kiziltepe and Basar Bilgicer. Liposomal Bortezomib Nanoparticles via Boronic Ester Prodrug Formulation for Improved Therapeutic Efficacy in Vivo. Journal of Medicinal Chemistry2014; 57(12), 5282-92.
Michael W. Handlogten, Ana P. Serezani, Mark H. Kaplan, and Basar Bilgicer. A Heterobivalent Ligand Inhibits Mast Cell Degranulation via Selective Inhibition of Allergen-IgE Interactions In Vivo. Journal of Immunology2014; 192(5), 2035-2041.
Michael W. Handlogten, Ana P. Serezani, Mark H. Kaplan, and Basar Bilgicer. What potential do heterobivalent inhibitors have for the treatment of severe allergic reactions? Immunotherapy2014; 6(3), 223-225.
Haihua Xiao, Gavin T. Noble, Jared F. Stefanick, Ruogu Qi, Tanyel Kiziltepe, Xiabin Jing, and Basar Bilgicer. Photosensitive Pt(IV)-azide prodrug-loaded nanoparticles exhibit controlled drug release and enhanced efficacy in vivo. Journal of Controlled Release2014; 173, 11-17.
Gavin T. Noble, Jared Stefanick, Jonathan Ashley, Tanyel Kiziltepe, and Basar Bilgicer. Ligand-Targeted Liposome Design: Challenges and Fundamental Considerations. Trends in Biotechnology2014; 32(1), 32-45.
Jared Stefanick, Jonathan Ashley, and Basar Bilgicer. Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles Through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. ACS Nano2013;7(9), 8115–8127.
Michael W. Handlogten, Tanyel Kiziltepe, Ana P. Serezani, Mark H. Kaplan, and Basar Bilgicer. Selective Inhibition of Weak-Affinity Epitope-IgE Interactions via Heterobivalent Inhibitor Design Prevents Mast Cell Degranulation. Nature Chemical Biology2013;9(12), 789-795.
Nathan J. Alves, William Cusick, Jared F. Stefanick, Jonathan D. Ashley, Michael W. Handlogten, and Basar Bilgicer. Functionalized liposome purification via Liposome Extruder Purification (LEP). Analyst2013; DOI: 10.1039/c3an00680h.
Nathan J. Alves, Nur Mustafaoglu, and Basar Bilgicer. Oriented Antibody Immobilization by Site-Specific UV Photocrosslinking of Biotin at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. Biosensors and Bioelectronics2013; DOI: 10.1016/j.bios.2013.05.052.
Nathan J. Alves, Matthew M. Champion, Jared F. Stefanick, Michael W. Handlogten, Demetri T. Moustakas, Yunhua Shi, Bryan F. Shaw, Rudolph M. Navari, Tanyel Kiziltepe and Basar Bilgicer. Selective Photocrosslinking of Functional Ligands to Antibodies via the Conserved Nucleotide Binding Site. Biomaterials2013; DOI: 10.1016/j.biomaterials.2013.03.082.
Michael W. Handlogten, Jared F. Stefanick, Nathan J. Alves and Basar Bilgicer. Non-chromatographic Affinity Precipitation Method for the Purification of Bivalently Active Pharmaceutical Antibodies from Biological Fluids. Analytical Chemistry2013; DOI: 10.1021/ac4008286.
Haihua Xiao, Jared Stefanick, Xiaoyu Jia, Xiabin Jing, Tanyel Kiziltepe, Yu Zhang, and Basar Bilgicer. Micellar Nanoparticle Formation via Electrostatic Interactions for Delivering Multinuclear Platinum (II) Drugs. ChemmComm2013; DOI: 10.1039/C3CC39119A.
Jared Stefanick, Jonathan Ashley, Tanyel Kiziltepe, and Basar Bilgicer. A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes. ACS Nano2013 Feb 19; DOI: 10.1021/nn305663e.
Michael W. Handlogten, Tanyel Kiziltepe, and Basar Bilgicer. Design of a Heterotetravalent Synthetic Allergen That Reflects Epitope Heterogeneity and IgE Antibody Variability to Study Mast Cell Degranulation. Biochemical Journal2013 Jan 1;449(1):91-9, DOI: 10.1042/BJ20121088.
Nathan J. Alves, Samuel D. Stimple, Michael W. Handlogten, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer. A Small Molecule Based Affinity Chromatography Method for Antibody Purification via Nucleotide Binding Site Targeting. Analytical Chemistry2012,-, DOI: 10.1021/ac300952r.
Michael W. Handlogten, Tanyel Kiziltepe, Nathan J. Alves, and Basar Bilgicer. Synthetic Allergen Design Reveals the Significance of Moderate Affinity Epitopes in Mast Cell Degranulation. ACS Chemical Biology2012,-, DOI: 10.1021/cb300193f.
Yunhua Shi, Richard A. Mowery, Jonathan Ashley, Michelle Hentz, Alejandro J. Ramirez, Basar Bilgicer, Hilda Slunt-Brown, David R. Borchelt, and Bryan F. Shaw. Abnormal SDS-PAGE migration of cytosolic proteins can identify domains and mechanisms that control surfactant binding. Protein Science2012,21, 1197-1209.
Nathan J. Alves, Tanyel Kiziltepe, and Basar Bilgicer. Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. Langmuir2012,28, 9640-9648.
Tanyel Kiziltepe, Jonathan D. Ashley, Jared M. Stefanick, Yu Meng Qi, Nathan J. Alves, Michael W. Handlogten, Rudolph Navari, and Basar Bilgicer. VLA4 Targeting Multifunctional Nanoparticles Overcome Drug Resistance and Inhibit Tumor Growth in Multiple Myeloma. Blood Cancer Journal2012, doi:10.1038/bcj.2012.10.
Eric T. Mack, Phillip W. Snyder, Raquel Perez-Castillejos, Başar Bilgiçer, Demetri T. Moustakas, Manish J. Butte, and George M. Whitesides. Dependence of Avidity on Linker Length for a Bivalent Ligand-Bivalent Receptor Model System. J. Am. Chem. Soc.2012,134(1), 333-345
Stefanick, J. F.; Kiziltepe, T.; Handlogten, M. W.; Alves, N. J.; Bilgicer, B. Enhancement of Antibody Selectivity via Bicyclic Complex Formation. J. Phys. Chem. Lett.2012,3, 598-602.
Michael W Handlogten, Tanyel Kiziltepe, Demetri T Moustakas and Basar Bilgicer. Design of a Heterobivalent Ligand to Inhibit IgE Clustering on Mast Cells. Chemistry and Biology2011,18, 1179-1188.
Abhimanyu Paraskar, Shivani Soni, Kenneth T. Chin, Padmaparna Chaudhuri, Katherine W. Muto, Julia Berkowitz, Michael W. Handlogten, Nathan J. Alves, Başar Bilgicer, Daniela M. Dinulescu, Raghunath A. Mashelkar, Shiladitya Sengupta. Harnessing structure‐activity relationship to engineer a novel cisplatin nanoparticle for improved antitumor efficacy. Proc. Natl. Acad. Sci. U.S.A.2010,28, 12435-12440.
Bryan F. Shaw, Haribabu Arthanari, Andrew Lee, Armando Durazo, Dominique P. Frueh, Michael P. Pollastri, Basar Bilgicer, Steven P. Gygi, Gerhard Wagner, and George M. Whitesides. Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability. J. Am. Chem. Soc.2010,132, 17411-17425.
Basar Bilgicer, Samuel W. Thomas III, Bryan F. Shaw, George K. Kaufman, Vijay M. Krishnamurthy, Lara A. Estroff, Jerry Yang, and George M. Whitesides A Non-Chromatographic Method for the Purification of a Bivalently Active Monoclonal IgG Antibody from Biological Fluids. J. Am. Chem. Soc.2009,131, 9361-9367.