Media Mentions: November 2013
October 2013 November 2013 December 2013
Nature
Immunology: Allergy's Achilles' heel?
November 14, 2013
Snippet from article: This diversity in the affinity of the IgE response is addressed in the study of Handlogten et al.1. Using a defined synthetic multivalent 'allergen' with both high- and low-affinity binding sites for IgE, they show that weak interactions are critical; importantly, they also demonstrate that blocking these interactions can inhibit an allergic reaction both in vitro and in vivo.
Nature SciBX (Science-Business eXchange) : IgE - Indication : Allergy
November 07, 2013
In vitro and mouse studies suggest inhibiting weak affinity allergen–IgE interactions could help prevent allergies. In a rat cell culture model, tetravalent allergens were shown to bind IgE and induce mast cell degranulation, an initial step in triggering allergic reactions.